Linezolid is used to treat certain bacterial infections in many different parts of the body, including certain types of skin infections or pneumonia. Linezolid belongs to the family of medicines called antibiotics. It works by killing bacteria or preventing their growth.
General Information: –
CAS No – 165800-03-3
Molecular Formula / Molecular Weight – C16H20FN3O4 = 337.35
Physical State (20 deg.C) – Solid
Store Under Inert Gas – Store under inert gas
Condition to Avoid – Air Sensitive
PubChem Substance ID – 468592166
Specifications: –
Appearance – White to Light yellow powder to crystal
Purity(HPLC) – min. 98.0 area%
Melting point – 177.0 to 181.0 °C
Solubility in water Insoluble
Degree of solubility in water – 610 mg/l 25 °C
Solubility (slightly sol. in) – dichloromethane
Solubility (insoluble in) – Ethanol
Applications: –
Linezolid (U-100766) is a synthetic oxazolidinone antibacterial which has excellent activity against virtually all important Gram-positive pathogens, including methicillin-resistant staphylococci (e.g. MRSA), penicillin-resistant pneumococci, macrolide-resistant streptococci, and vancomycin-resistant enterococci (VRE). In addition, the in vitro spectrum of activity of linezolid also includes certain Gram-negative bacteria and anaerobic bacteria. It has been reported that linezolid binds to a site on the bacterial 23S ribosomal RNA of the 50S subunit and prevents the formation of a functional 70S initiation complex, which is an essential component of the bacterial translation process. In recent years, the emergence of bacteria resistant to linezolid has become a problem.