Edaravone is also known as 1-Phenyl-3-methyl-5-pyrazolone is a reagent, known as PMP, used to derivatize monosaccharides for the study of polysaccharides composition and structure, and for the dosage of carbohydrates in complex media.
General Information: –
CAS No – 89-25-8
Molecular Formula / Molecular Weight – C10H10N2O = 174.20
Physical State (20 deg.C) – Solid
Store Under Inert Gas – Store under inert gas
Condition to Avoid – Air Sensitive
PubChem Substance ID – 87572698
Specifications: –
Appearance – White to Orange to Green powder to crystal
Purity(HPLC) – min. 98.0 area%
Purity(Neutralization titration) – min. 98.0 %
Melting point – 128.0 to 131.0 °C
Boiling Point – 287 °C/265 mmHg
Solubility in water – Insoluble
Solubility (slightly sol. in) – Chloroform,Dimethylformamide,Alcohol,Benzene
Applications: –
Edaravone (MCI-186) is a strong free radical scavenger and a powerful antioxidant. There have been many reports describing that free radicals such as hydroxyl radical (·OH) play a major causative role in the development of cerebral vascular disorder resulting from ischaemia. During ischaemia or ischemic reperfusion, the hyperactivity of a metabolic system of arachidonic acid increases the production of free radicals. These free radicals peroxidize unsaturated fatty acid of cell membrane lipids leads to cell membrane injury. Besides, oxidative stress is believed to contribute to the pathogenesis of amyotrophic lateral sclerosis (ALS). Edaravone inhibits lipid peroxidation, and thereby prevents oxidative damage to brain cells or neurons. Consequently, edaravone improves of neurological symptoms, and inhibits the progression of ALS